Solid Phase Synthesis - Combinatorial Chemistry

A highly efficient and general protocol for traceless, directed C3-selective C-H borylation of indoles with [Ni(IMes)2] as the catalyst is reported. Activation and borylation of N-H bonds by [Ni(IMes)2] is essential to install a Bpin moiety at the N-position as a traceless directing group, which enables the C3-selective borylation of C-H bonds. The N-Bpin group which is formed is easily Direct Acyl Substitution of Carboxylic Acids: A Chemoselective O- to N-Acyl Migration in the Traceless Staudinger Ligation. Chemistry - A European Journal 2012, 18 (45) , 14444-14453. DOI: 10.1002/chem.201201773. Minisci alkylation is of prime importance for its applicability in functionalizing diverse heteroarenes, which are core structures in many bioactive compounds. In alkyl radical generation processes, precious metal catalysts, high temperatures and excessive oxidants are generally involved, which lead to susta Most popular 2018-2019 organic chemistry articles An approach combining traceless Staudinger ligation and protease‐catalyzed N‐terminal azidonation has been shown to be efficient for the convergent synthesis of glycopeptides without the cysteine limitation of native chemical ligation. Mar 10, 2020 · Traceless Linkers in combinatorial chemistry. In some case, the starting materials are loaded onto the resin in one form, such as carboxylic acid, and cleaved in another form; a carboxamide for example. Other Staudinger ligation induced macrocyclizations have been published previously by Maarseveen and co-workers, who successfully used the Raines ligation reagent for the synthesis of a series of medium-sized lactams. 4 Wong and co-workers reported the synthesis of 14 different glycopeptides through the traceless Staudinger Ligation. 5 For this work, they also developed a protease-catalyzed

“Traceless” solid-phase synthesis of furans via 1,3

Chemistry | Raines Lab MIT

Traceless - definition - English

“Traceless” solid-phase synthesis of furans via 1,3 This chemistry provides a method for preparing combinatorial libraries of functionalized furans and features cycloreversion as a new synthetic strategy for "traceless" synthesis of small organic molecules. 1997 Elsevier Science Ltd. Combinatorial chemistry has rapidly become a key tool in contemporary pharmaceutical research.2 To date, the most Traceless synthesis of protein thioesters using enzyme A traceless thioester-producing protocol featuring carboxypeptidase Y-mediated hydrazinolysis of cysteinyl prolyl leucine-tagged peptides has been developed. The hydrazinolysis followed by thioesterification affords cysteinyl prolyl thioesters. Self-editing of the tag and subsequent trans -thioesterification yields peptide thioesters.